A US outpost in southern Syria was attacked on Wednesday, but there were no reports of any American casualties from the blast, US officials said, adding it was too early to say who was responsible for the attack.
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One of the officials said it was believed to have been a drone attack.
The garrison, known as Tanf, is located in a strategic area near Syria's Tanf border crossing with Iraq and Jordan.
The garrison was first set up when Islamic State fighters controlled eastern Syria bordering Iraq but since the militants were driven out, it is seen as part of the larger US strategy to contain Iran's military reach in the region.