A Palestinian terrorist drove his car into two Israeli pedestrians near the Gush Etzion region of Judea and Samaria, south of Jerusalem, Friday.
A police spokesman said an officer who had been near the scene opened fire after the attacker rammed his car into people by the roadside near the Israeli settlement of Elazar.
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Israel's Magen David Adom ambulance service said that one of the Israelis, Nachum Navis, 17, was unresponsive and "in severe condition with multisystem trauma" and that the other, Navis' sister Noam, 19, had sustained moderate injuries.
Dozens of Israeli troops and medics were at the scene. The alleged attacker's vehicle, which bore Israeli license plates that allow greater freedom of movement in both Israel and the West Bank, was overturned by the roadside. Police said the attacker had been driving along a road which weaves past Palestinian towns and Israeli settlements.
The incident took place not far from where the body of an off-duty soldier was found stabbed earlier this month. Israel last week arrested Palestinian suspects in the killing of the 18-year-old soldier, Dvir Sorek.
Two Palestinian youths stabbed an Israeli policeman in Jerusalem's Old City on Thursday and were shot by officers, killing one of them.