Israeli Defense Minister Avigdor Lieberman will meet on Thursday with his Russian counterpart Sergei Shoigu in Moscow, Israel's Defense Ministry said in a statement on Monday.
The meeting comes against the backdrop of Israeli calls for an end to any Iranian military presence in Syria.
Lieberman will be joined by Director of Military Intelligence Maj. Gen. Tamir Heyman, senior Mossad officials and Director of the Defense Ministry's Political-Military Affairs Bureau Zohar Palti.
The Israeli minister is expected to ask Shoigu for clarifications over remarks by Russian Foreign Minister Sergey Lavrov, who hinted Monday that all foreign troops, including those sent by Iran, would soon leave Syria.
"The withdrawal of all non-Syrian forces must be carried out on a mutual basis, this should be a two-way street. The result of this work should be a situation when representatives of the Syrian Arab Republic's army stand at Syria's border with Israel," Lavrov said.
Israeli officials said Lavrov's statement was most likely made with Russian President Vladimir Putin's approval.
It remains unclear whether the Russian position means Moscow has essentially accepted Jerusalem's demand to push Iranian troops and Iranian-backed Shiite militias to at least 50 kilometers (30 miles) away from the Syria-Israel border.
If so, this would spell a change of the previous agreements between Russia and Iran, by which Iranian-backed forces could deploy as close as 20 kilometers (12 miles) from the border.
Several officials attributed the change in Russia's position to recent Israeli strikes against Iranian assets in Syria, and primarily to Operation House of Cards, in which the Israeli Air Force bombed some 50 Iranian targets in Syria after Iranian militias fired 20 rockets at Israeli military posts in the Golan Heights.